摘要
为探讨载脂蛋白Ｅ（ＡｐｏＥ）基因多态性与血管性痴呆（ｖａｓｃｕｌａｒｄｅｍｅｎｔｉａ，ＶＤ）的关系，采用单链构象多态性分析（ＰＣＲ－ＳＳＣＰ）检测了３７例ＶＤ患者的ＡｐｏＥ基因型，并与４０例同龄对照组及４０例非痴呆脑梗塞组比较，同时检测血脂、脂蛋白及部分载脂蛋白。结果表明，ＶＤ组ε４基因频率明显高于对照组（Ｐ＜０．０１）和非痴呆脑梗塞组（Ｐ＜０．０５），ＶＤ患者中携ε４等位基因者血ＴＣ及ＬＤＬ－Ｃ水平显著高于携ε２、ε３者。提示：ε４基因可能是ＶＤ的危险因子，其机理可能与大脑血管性和变性性损害有关。
Apolipoprotein E(Apo E) gene polymorphism and vascular dementia (VD) were studied. The single strand conformation polymorphism (PCR SSCP) was used to detect ApoE genotype in 37 VD patients, 40 patients with nondemented cerebral infarction and 40 agematched controls. Meanwhile, the serum levels of lipids, lipoprotein and partial apolipoprotein were determined. The results showed that the frequency of ε4 allele in VD was significantly higher than that in agematched controls ( P< 0.01) and nondemented cerebral infarction controls ( P<0.05) . The patients with ε4 allele had high levels of TC and LDL C as compared with the groups with ε2 and ε3 alleles. It suggests that ε4 allele increases the risk for VD. The mechanism could involve the degenerative and vascular insults of brain.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
1997年第1期31-34,共4页
Chinese Journal of Medical Genetics
关键词
载脂蛋白E
基因多态性
血管性
痴呆
Apolipoprotein E Gene polymorphism Vascular dementia Genotype Allele
