摘要
目的研究阿托伐他汀对脑梗死患者的血脂、颈动脉内-中膜厚度(IMT)及复发率的影响。方法 59例合并有高脂血症和颈动脉粥样硬化的脑梗死患者随机分为阿托伐他汀组(29例)和对照组(30例)。两组患者均给予脑梗死常规治疗;阿托伐他汀组患者加用阿托伐他汀20 mg/d,连用12个月。在治疗前及治疗后3、6、12个月时,检测患者的血脂,用彩色多普勒超声仪检测颈动脉内-中膜厚度(IMT)。统计治疗后12个月时脑梗死复发的例数。结果阿托伐他汀组治疗后各时间点的血胆固醇(TC)、低密度脂蛋白(LDL)水平显著低于治疗前及对照组(均P<0.01);治疗后12个月时高密度脂蛋白(HDL)水平显著高于治疗前及对照组(均P<0.05)。阿托伐他汀组治疗后6个月、12个月时颈动脉IMT显著低于治疗前及对照组(P<0.05～0.01);对照组治疗后12个月时则明显高于治疗前(P<0.05)。治疗12个月后,阿托伐他汀组无脑梗死复发,对照组脑梗死复发3例(10%)。结论阿托伐他汀能显著降低脑梗死患者的血TC、LDL水平,长期治疗可降低颈动脉IMT和脑梗死的复发率。
Objective To study the influence of Atorvastatin on blood lipids,carotid intimal medial thickness(IMT) and recurrence rate in cerebral infarction patients.Methods Fifty-nine cerebral infarction patients with hyperlipidemia and carotid artery atherosclerosis were randomly divided into Atorvastatin group(29 cases) and control group(30 cases).All the patients in the two groups were received conventional treatment for cerebral infarction.The patients in the Atorvastatin group were added with a daily dose of 20 mg Atorvastatin for 12 months.Serum lipid levels and IMT which was obtained by color flow Doppler sonography were checked respectively before treatment and at 3,6 and 12 months after treatment.The cases of recurrent cerebral infarction were count after the treatment of 12 months.Results The levels of blood cholesterol(TC),the level of blood low density lipoprotein(LDL) in Atorvastatin group at each time points were significantly lower than those before treatment and in the control group(all P<0.01).At 12 months after treatment,the level of blood high density lipoprotein(HDL) in the Atorvastatin group was significantly higher than those before treatment and in control group(all P<0.05).At 6 and 12 months after treatment,the carotid IMT in Atorvastatin group were significantly thinner than those before treatment and control group(P<0.05-0.01).At 12 months after treatment,the carotid IMT in control group was significantly higher than that before treatment(P<0.05).At 12 months after treatment,there was no recurrent cerebral infarction in the Atorvastatin group,meanwhile there were 3 cases of recurrent cerebral infarction in control group(10%).Conclusion Atorvastatin can significantly reduce the levels of blood TC and LDL-C.The long-term treatment with Atorvastatin can effectively reduce carotid IMT and recurrence rate of cerebral infarction.
出处
《临床神经病学杂志》
CAS
北大核心
2013年第2期127-129,共3页
Journal of Clinical Neurology
关键词
阿托伐他汀
脑梗死
血脂
颈动脉内-中膜厚度
Atorvastatin
cerebral infarction
blood lipids
carotid intimal medial thickness
