摘要
目的:探讨二神丸、二神丸去姜枣和四神丸对脾虚泄泻作用的组方差异性。方法:建立大黄致脾虚泄泻模型,设立空白组、模型组、参苓白术散组、二神丸去姜枣组、二神丸组、四神丸组和四神汤组共七组。观察各组对血浆胃动素、胃泌素含量及小肠推进的影响。结果:各给药组的胃动素、胃泌素含量均较模型组升高,并能抑制正常和脾虚小鼠的炭末推进率。结论:二神丸、二神丸去姜枣和四神丸通过调节Gas、Mtl起作用,其作用效果之差异可能与以下因素有关:(1)四神汤升高胃动素含量和抑制小肠推进运动效果最佳,与五味子散和二神丸具有协同作用有关。(2)在升高胃动素含量和抑制小肠推进作用两方面,四神汤去掉五味子散后,补骨脂、肉豆蔻和生姜、大枣未体现协同作用。(3)在升高胃泌素含量方面,补骨脂、肉豆蔻是主要因素,生姜、大枣是非主要因素。(4)补骨脂和肉豆蔻是抑制小肠推进运动的主要因素。
Objective ：To explore the different functions of ershen pill （ESP） ＂subtract ginger and jujube from ershen pill＂ （SGJESP） and sishen pill （SSP） in treating diarrhea. Methods ： Wistar Rat model of diarrhea was induced with rhubarb decoction. To observe the gastrin content, the motilin content and the intestinal propulsion change performed by the three prescriptions. Results ：Compared with those of model group , the contents of gastrin and motilin in other treating group are significantly increased. The three prescriptions can decrease the charcoal powder propulsion rate. Conclusion ：The effect of ESP, SGJSSP and SSP on wistar diarrhea of rats may regulate the contents of gastrin and motilin to treat them, the difference of them may have to do with the factors following： （1） SSP can increase the motilin content most markly because of the harmony of wuwei -zi powder（WWP） and ESP. （2） Substracting WWP from SSP, the traditional medicine remaining dont perform an excellent coordination in increasing the content of motilin and restraining the intestinal propulsion. （3） Malaytea Scurfpea Fruit and Myristica fragrans Houtt are the important factors ,Ginger and jujube are the unimportant factors in increasing the gastrin content. （4） Malaytea Scurfpea Fruit and Myristiea fragrans Houtt are the important factors in restraining the intestinal propulsisn.
出处
《辽宁中医杂志》
CAS
北大核心
2007年第6期728-730,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
黑龙江省中医药管理局中医药重点科研项目
黑龙江中医药大学校基金资助项目(ZHY06-279)
关键词
二神丸
四神丸
泄泻
胃动素
胃泌素
小肠推进
ershen pill
sishen pill
diarrhea
Mtl
Gas
intestinal propulsion
