摘要
实验选用健康雄性Ｗｉｓｔａｒ大鼠３４只，鸟拉坦腹腔麻醉，人工呼吸条件下，髂总动脉插管直接描记血压．鼠头固定在立体定位仪上，按Ｐｅｌｅｇｒｉｎｏ图谱定位，将微量注射针头插入孤束核．比较注药前后刺激迷走神经中枢端所产生的加压反应．结果发现孤束核内微量注入β—内啡肽（β—ＥＰ）可减弱迷走—加压反应，而甲硫脑啡肽（Ｍ—ＥＫ）则使加压反应增强．如果先注入纳洛酮后再注入以上两种药物，β—ＥＰ的作用消失，但Ｍ—ＥＫ的作用仍然存在。
urethane anaesthetized and artificially ventilated rats were used in the experiments. The results were as follows: Microinjection of β_endorphin (β_EP) into the nucleus of the tractus solitarius decreased Vagus_pressor response (VPR) value, of methionine_enkephalin(M_EK) increased VPR. First microinjection naloxone, the β_EP and M_EK, β_EP lose effect, M_EK still keep its effect. The results suggest that the endorphin be important in VPR.
出处
《曲阜师范大学学报（自然科学版）》
CAS
1997年第1期89-91,共3页
Journal of Qufu Normal University(Natural Science)
关键词
迷走加压反应
孤束核
内啡肽
甲硫脑腓肽
纳洛酮
vagus_pressor response nucleus tractus solitarius β_endorphin Methionine_enkephalin naloxone
