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CXC亚家族趋化因子受体-4在急性白血病中的表达及临床意义 被引量：1

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摘要 目的探讨急性白血病(AL)细胞上CXC亚家族趋化因子受体-4(CXCR4)的表达及临床意义。方法采用四色流式细胞仪检测33例AL患者和7例正常对照者骨髓单个核细胞(BMMNC)表面CX- CR4的表达情况,并分析其与临床表现及疗效的关系。结果AL患者CXCR4的表达水平明显高于正常对照组(P<0.01);急性淋巴细胞白血病(ALL)的表达又高于急性髓细胞白血病(AML)(P<0.01)。髓外浸润组CXCR4表达高于无髓外浸润组(P<0.05)。CXCR4的高表达组髓外浸润发生率高于CXCR4低表达组(P<0.05)。CXCR4的高表达且外周血白细胞(WBC)增高组髓外浸润的发生率最高,CXCR4低表达且WBC不增高髓外浸润组的发生率最低(P<0.05)。化疗敏感组CXCR4的表达低于耐药组(P<0.05)。结论AL患者的BMMNC存在着CXCR4的高表达,不同类型的AL患者CXCR4的表达存在差异,ALL表达高于AML。AL患者CXCR4高表达且WBC增高预示髓外浸润的可能性大。AL患者CXCR4的高表达预示白血病细胞对化疗不敏感,是判断预后的指标之一。
作者 杨桂玲 金北平 杨碧云 余莉 邹湉
机构地区 南昌大学第二附属医院血液科血液病研究所 山东省临沂市人民医院
出处 《中国综合临床》 北大核心 2007年第7期610-612,共3页 Clinical Medicine of China
关键词 急性白血病 CXC亚家族趋化因子受体-4 基质细胞衍生因子-1
分类号 R733.71 [医药卫生—肿瘤]
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参考文献10

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共引文献26

同被引文献12

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引证文献1

中国综合临床
2007年 第7期

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