期刊文献+

急性淋巴细胞性白血病骨髓单个核细胞CD_(11a)的表达及临床意义

原文传递
导出
摘要 目的探讨淋巴细胞功能相关抗原-1(LFA-1)的α链CD11 a在急性淋巴细胞性白血病(ALL)的表达情况及其临床意义。方法采用免疫酶标ABC法检测20例初治ALL患者和8例正常对照骨髓单个核细胞CD11 a的表达。结果CD11 a在ALL患者骨髓单个核细胞的表达率(35.23±13.57)%明显低于对照组(87.13±5.38)%(P<0.05),治疗后完全缓解组的表达率(44.64±10.15)%显著高于未缓解组(23.72±6.13)%(P<0.05)。结论ALL患者骨髓单个核细胞的CD11 a表达异常,对ALL的预后判断有一定意义。
出处 《中国医师杂志》 CAS 2006年第9期1266-1267,共2页 Journal of Chinese Physician
  • 相关文献

参考文献8

  • 1Keizer GD,Borst J,Figdor CG,et al.Biochemical and functional characteristics of human leukocyte membrane antigen family LFA-1,Mo-1 and p150,95.Eur J Immunol,1985,15(11):1142-1148.
  • 2Brouwer RE,Hoefnagel J,Borger DBB,et al.Expression of co-stimulatory and adhesion molecules and chemokine or apoptosis receptors on acute myeloid leukaemia:high CD40 and CD11a expression correlates with poor prognosis.Br J Haematol,2001,115(2):298-308.
  • 3刘廷析,刘秀芳,向建平,邹萍,周剑锋,陈燕,喻东姣,李崇渔.急性髓系白血病细胞侵袭能力与粘附分子表达关系探讨[J].中华血液学杂志,1997,18(1):29-31. 被引量:20
  • 4Tibbetts SA,Chirathaworn C,Nakashima M,et al.Peptides derived from ICAM-1 and LFA-1 modulate T cell adhesion and immune function in a mixed lymphocyte culture.Transplantation,1999,68(5):685-692.
  • 5De Waele M,Renmans W,Jochmans K,et al.Different expression of adhesion molecules on CD34+ cells in AML and B-lineage ALL and their normal bone marrow counterparts.Eur J Haematol,1999,63(3):192-201.
  • 6Mustjoki S,Alitalo R,Elonen E,et al.Intercellular adhesion molecule-1 in extravasation of normal mononuclear and leukemia cells.Br J Haematol,2001,113 (4):988-1000.
  • 7Kawada H,Fukuda R,Yoshida M,et al.Clinical significance of LFA-1 expression in adult acute myeloid leukemia.Leuk Res,1996,20(4):327-332.
  • 8Brouwer RE,Zwinderman KH,Kluin-Nelemans HC,et al.Expression and induction of costimulatory and adhesion moleucules on acute myeloid leukemic cells:implications for adoptive immunotherapy.Exp Hematol,2000,28(2):161-168.

共引文献19

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部