摘要
目的探讨活血消瘕胶囊对子宫腺肌病模型大鼠血液流变学、血清CA125的影响及血管内皮细胞生长因子（VEGF）、Bcl-2蛋白（Bcl-2）在动物异位内膜组织中的表达及意义。方法采用外科手术诱导法建立子宫腺肌病大鼠模型，第8周腹腔静脉取血检测大鼠血液流变学的变化及血清CA125含量。用免疫组化方法检测VEGF、Bcl-2在大鼠异位内膜组织中的表达。结果活血消瘕胶囊能降低模型大鼠血液流变学、血清CA125值；VEGF、Bcl-2组织表达减弱。结论活血消瘕胶囊可降低子宫腺肌病模型大鼠血液流变性及VEGF、Bcl-2在异位内膜的表达，能抑制异位子宫内膜的种植，促进异位内膜萎缩。
Objective To discuss the effects of Huoxue-xiaozheng Capsule on blood rheology, serum CA125, and expression of vascular endothelial growth factor （VEGF） and Bcl-2 Protein （Bcl-2） of endometriosis tissue. Methods Establish the rat models of adenomyosis using surgical induction, and divide them into 4 groups stochastically. 1 group was not filled stomach, and the other 3 groups were filled with normal saline, Huoxue-xiaozheng capsule and mifepriston separately. After 8 weeks, examine the indicator of blood rheology and serum CA125, and the expression of VEGF, Bcl-2 in rats＇endometriosis tissue. Results Huoxue-xiaozheng capsule has the function of lowing the value of blood rheology, serum CA125, and weakening tissue expression of VEGF and Bcl-2. Condusions Huoxue-xiaozheng capsules had the function of lowing the value of blood rheology and weakening the expression of VEGF, Bcl-2 in rats＇ endometriosis tissue, inhibiting growth of ectopic endometrium and promoting its atrophy.
出处
《国际中医中药杂志》
2007年第3期137-140,共4页
International Journal of Traditional Chinese Medicine
基金
山东省自然科学基金资助项目（No.2000C-02）
