摘要
目的观察克癫胶囊的抗惊厥作用。方法采用克癫胶囊251、5、20mg/(kg.d)灌胃给药,观察最大电休克致小鼠惊厥率和筒箭毒碱侧脑室注射致大鼠惊厥率及戊四唑诱发小鼠惊厥的抗惊厥作用。结果克癫胶囊灌胃给药后能显著降低最大电休克致小鼠惊厥率和筒箭毒碱致大鼠惊厥率;能明显减少腹腔灌注士的宁致小鼠惊厥率,能明显延长戊四唑致小鼠惊厥诱导期。结论表明克癫胶囊具有明显的抗惊厥作用。
Objective To study anti - convulsion effect of Ke - dian Capsules in mice and rats. Methods Sample dosages were used 15mg, 20mg, 25mg/（kg·d） by gstro gavage .The conmlsion rates was induced by maximtnn electric shock, ip cardiazin mice and lateral intracereraL injection or cufine in rats were observed. Results As mentioned above, the three convulsion rates were all reduced significantly and the induce period of convulsion induced by cardiazole in mice was Prolonged evidently. Conclusion The Ke - dian capsule has obvious anti - convulsion effect.
出处
《宁夏医学杂志》
CAS
2006年第1期48-49,共2页
Ningxia Medical Journal
