摘要
目的了解凋亡抑制蛋白生存素(Survivin)在子宫腺肌病患者病灶?在位内膜中的表达情况。方法采用免疫组化抗生物素蛋白-过氧化物酶染色法(SP法)检测子宫腺肌病患者(22例)异位病灶?在位内膜及对照组(30例子宫肌瘤)子宫内膜标本中生存素的表达并比较。结果生存素在研究组异位病灶中广泛表达,表达的强度显著高于其在位内膜和对照组子宫内膜,增殖期高于分泌期;研究组在位内膜的生存素表达也高于对照组内膜;无论是研究组在位内膜还是对照组子宫内膜中生存素的表达均不随月经周期变化。结论生存素的过度表达可能参与了子宫腺肌病的发生与发展过程。
Objective To explore the expression of Survivin in adenomyosis tissues and in eutopic endometrium. Methods Immunohistochemical streptavidin- biotin peroxidase was applied to compare the expression of Survivin between ectopic lesions within myometrium and eutopic endometrium from 22 women with adenomyosis and normal endometrium from 30 healthy controls. Resells The expression of Survivin in ectopic lesion of adenomyosis group was significantly higher than that of eutopic endometrium in adenomyosis group and higher than normal endometrium in control group. The Survivin expression of ectopic lesion was higher in proliferative phase than in secretion phase. The Survivin expression in eutopic endometrium in adenomyosis group was higher than normal endome- trium in healthy control. Neither eutopic endometrium in adenomyosis group nor normal endometrium in control group showed cyclic variation of the Survivin expression. Conclusion The overexpression of Survivin plays an important role in the pathogenesis and the development of adenomyosis.
出处
《中国妇产科临床杂志》
2007年第3期213-215,198,I0002,共5页
Chinese Journal of Clinical Obstetrics and Gynecology
基金
北京市科委基金(H030930040230)资助
