摘要
目的评价支气管动脉化疗灌注联合多极射频治疗中晚期肺癌的临床疗效。方法对32例失去手术机会或放弃手术治疗的中晚期肺癌患者,在进行常规支气管动脉化疗灌注的同时,于首次化疗灌注后2周,在CT引导下对病灶进行多极射频治疗1次。随访并记录术后半年、1年、2年、3年的有效率与患者生存率,与单纯进行常规支气管动脉化疗灌注的38例对照组进行同期有效率与生存率的比较。结果联合治疗组术后半年、1年、2年、3年的有效率/生存率分别为:87.5%/96.9%、71.9%/81.3%、34.4%/46.9%、12.5%/21.9%。对照组有效率/生存率分别为:63.2%/78.9%、36.9%/52.6%、26.3%/36.8%、5.3%/7.9%,联合治疗组有效率与生存率均明显高于对照组,统计学有明显差异(P<0.05)。结论支气管动脉化疗灌注联合多极射频治疗中晚期肺癌,疗效明显优于单纯支气管动脉化疗灌注(P<0.05),同时可明显提高患者的生存率,是一种较为理想、安全有效的综合性治疗手段,值得推广应用。
Objective To evaluate the efficacy of bronchial artery infusion （BAI） combined with radiofrequency ablation （RFA） in advanced stage lung cancer. Methods 32 patients of advanced stage lung cancer, who had lost opportunity of operation or given up operation, while given routine BAI, were treated with CT-guided RFA 2 weeks after the first BAI. All 32 patients were followed-up in half, one, two and three years on efficiency and survival rate, and the results were com- pared with contrastive group of 38 patients treated with routine BAI only. Results The efficiency and survival rate of the combined group and the contrastive group in half, one, two and three years were 87. 5%/96. 9%, 71. 9%/81. 3%, 34.4%/46.9%, 12.5%/21.9% and 63.2%/78.9%, 36.9%/52.6%, 26.3%/36.8%, 5.3%/7.9% respectively. There was significant difference between the two groups （P〈0.05）. Conclusion Bronchial Artery Infusion combined with radiofrequency ablation is an ideal, safty, effective comprehensive treatment method for advanced stage lung cancer.
出处
《中国介入影像与治疗学》
CSCD
2007年第2期93-97,共5页
Chinese Journal of Interventional Imaging and Therapy
关键词
肺癌
支气管动脉灌注
射频
CT引导
Lung neoplasms
Bronchial artery infusion
Radiofrequency ablation
CT-guided
