摘要
目的探讨肿瘤型 M2丙酮酸激酶(TuM2-PK)在肺癌患者血中的表达水平及其临床应用价值。方法用 ELISA 法分别检测92例肺癌、77例良性肺部疾病患者和106名健康体检者血浆中的 TuM2-PK 表达水平,并进行比较分析。结果 TuM2-PK 浓度和阳性率分别为肺癌组22.1 U/ml和71%,良性肺疾病组10.5 U/ml 和4%,健康对照组8 U/ml 和3%,肺癌组明显高于后两组(P<0.01)。Ⅲ、Ⅳ期肺癌患者 TuM2-PK 阳性率(分别为83%和88%)高于Ⅰ或Ⅱ期肺癌(分别为43%和56%,P 均<0.05);有淋巴结转移患者 TuM2-PK 阳性率(79%)高于未发现转移患者(35%,P<0.05)。TuM2-PK 诊断肺癌的敏感度为71.0%,特异度为96.7%,阳性预测值91.5%,阴性预测值86.8%,准确性88.0%。结论 TuM2-PK 对肺癌的辅助诊断有较高的临床价值,并对临床分期、判断淋巴结转移及临床治疗具有一定的指导意义。
Objective To investigate the diagnostic values of tumor M2-PK in lung cancer. Methods The concentration of Tumor M2-PK in plasma was detected by ELISA in 106 health controls,77 benign lung disease patients and 92 lung cancer patients. Results TuM2-PK concentration in plasma and the positive rate were singificantly higher in lung cancer （22. 1 U/ml,71% ） than that in benign lung disease and in health controls （ 10. 5 U/ml,4% and 8 U/ml, 3% ） （P 〈 0. 01, respectively ）. The positive rates of TuM2-PK in the stage Ⅲ or Ⅳ （83% ,88% ） were higher than that of the stage Ⅰ or Ⅱ （43%, 56% ,P 〈 0. 05 ）. The positive rate of TuM2-PK levels was higher in lung cancer patients with lymph node metastasis （79%） than those without metastasis （35%, P 〈 0. 05 ）. The diagnostic sensitivity, specificity and accuracy were 71.0% ,96. 7% and 88.0%, respectively. Conclusion The measurement of TuM2-PK is of great clinical value for the diagnosis of lung cancer, and is helpful in the evaluation of lymph node metastasis, and TNM staging in cancer treatment.
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2007年第5期541-543,共3页
Chinese Journal of Laboratory Medicine
关键词
肺肿瘤
肿瘤标志
丙酮酸激酶
Lung neoplasm
Tumor marker
Pyruvate kinase
