摘要
目的探讨原发性肺癌患者血清中sEndoglin的表达水平及其临床意义。方法应用ELISA测定101例原发性肺癌患者、80例肺部良性疾病患者和50例健康对照者血清中sEndoglin水平。结果原发性肺癌组、肺部良性疾病组、健康对照组血清中sEndoglin水平分别是8.1、3.7、3.4μg/L。原发性肺癌组sEndoglin表达水平高于肺部良性疾病组和健康对照组(均P<0.05)。sEndoglin的水平与组织学分级、临床分期、肿瘤大小和是否转移有关(均P<0.05),与性别、年龄和组织学类型无关。结论血清sEndoglin在原发性肺癌中高表达,可鉴别肺部良恶性疾病,其表达水平有助于组织学分级、临床分期、肿瘤大小和淋巴结转移的判断。
Objective To analyze the expression level of serum soluble Endoglin in primary lung carcinoma and its clinical significance .Methods The level of serum soluble Endoglin was detected by ELISA in 50 health controls , 80 patients with benign lung disease and 101 patients with primary lung carcinoma .Results The serum level of soluble Endoglin in the primary lung carcinoma group ,the benign lung disease group and the health control group were 8 .1 ,3 .7 ,3 .4 μg /L respectively ,the primary lung carcinoma group was higher than the benign lung disease group and the health control group（P〈 0 .05） .Soluble Endoglin expression level was positively correlated with the histological grade ,clinical stage ,tumor size and metastasis（P 〈 0 .05） ,but had no relation with sex ,age and histological type . Conclusion The serum soluble Endoglin is highly expressed in primary lung carcinoma and can differentiate benign from malignant lung diseases ,its expression level is conducive to judgment of histological grade ,clinical stage ,tumor size and lymph node metastasis .
出处
《检验医学与临床》
CAS
2015年第18期2682-2683,共2页
Laboratory Medicine and Clinic
基金
广东省医学科研基金资助项目(A2014225)
