摘要
蛋白激酶CK2是一种在真核细胞中普遍存在的信使非依赖性丝/苏氨酸蛋白激酶,可横向介导多条信号途径,以级联和垂直的方式发挥作用,调节细胞的生长和凋亡。其精细调控一旦失衡,可诱发肿瘤;而其特异性抑制剂和以其为靶向的基因治疗可抑制肿瘤。以CK2调节为中心的致瘤机制研究和以CK2为靶点的肿瘤药物开发具有重要的临床应用价值。
Protein kinase CK2 is a ubiquitously expressed protein serine/threonine kinase present in all eukaryotes. It can intervene transversally into a multitude of signal pathways. It plays a key role in regulation of cell growth and apoptosis in a hierarchical and vertical manner. It was demonstrated that modest deregulation in the CK2 expression impacts a potent oncogenic potential to the cells. Moreover,inhibition of CK2 with specific chemical inhibitors or CK2-targeting antisense RNA may result in depression of tumor. Thus, studying the regulation mechanism of CK2 in tumorigenesis and developing new anti-cancer drugs by employing specific strategies against CK2 are of significant clinical value.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2007年第5期574-577,共4页
Chinese Pharmacological Bulletin
基金
国家重点基础研究发展规划(973规划)资助项目(No2007CB507403)
国家自然科学基金资助项目(No30672205)
广东省自然科学基金资助项目(No05011579)
2006年湛江市科技招标资助项目(NoZZ0605)
关键词
蛋白激酶CK2
信号转导
肿瘤发生
protein kinase CK2
signaling transduction
tumourigenesis
