摘要
目的研究新生儿缺氧缺血性脑病(HIE)血清IL-6水平、脑血流变化与新生儿缺氧缺血性脑病脑损伤程度关系。方法采用ELSIA法对41例HIE患儿和14例对照组新生儿血清IL-6水平进行检测,同时采用经颅多谱勒超声(TCD)技术观察双侧大脑中动脉收缩峰流速(Vs)、舒张末期流速(Vd)变化、脉动指数(RI)。结果轻、中、重度HIE患儿急性期血清IL-6水平均明显高于对照组水平(P<0.01),重度组增高尤其明显。中、重度组Vd、Vs低于对照组,RI指数重度组高于对照组(P<0.05)。血清IL-6水平与脑血流速度呈显著负相关(P<0.05)。结论检测血清IL-6水平和脑血流变化对于评价新生儿缺氧缺血性脑病脑损伤程度具有重要临床意义。
Objective To investigate the relationship of plasma interleukin-6 levels, hemodynamic changes in cerebral flow and brain damage in neonatal hypoxic ischemic encephalopathy（HIE）.Methods When the plasma interleukin-6 levels were detected using enzyme-linked immunoabsorbent assay（ELISA） in 41 neonatal hypoxic ischemic encephalopathy and 14 normal neonates,Systolic Velocity（Vs）,Diastolic Velocity（Vd） and aterial resistence index（R/） for middle cerebral artery（MCA） were detected by colour Doppler Sonography.Results IL-6 level was much higher in HIE than in the control group, and IL-6 level of severe group was the highest in three subgroups of HIE.Compared with those of the control groups, blood flow velocity decreased in the moderate and severe groups, while resistence index in severe group was higher than the control group. IL-6 level was significant negative correlation with blood flow velocity. Conclusion It is important clinical significance that IL-6 level and blood flow velocity are detected for estimating the severity of HIE and brain damage.
出处
《中国血液流变学杂志》
CAS
2007年第1期107-108,141,共3页
Chinese Journal of Hemorheology
关键词
脑缺氧
脑缺血
白细胞介素6
脑血流
Cerebral anoxia
Cerebral ischemia
Interleukin-6
Blood flow velocity
