摘要
[目的]观察鼻咽癌(nasopharyngeal carcinoma,NPC)组织PI3K和caspase-3的表达,探讨其相互关系及其在鼻咽癌发生发展中的作用。[方法]应用免疫组织化学法检测60例鼻咽癌与23例鼻咽部慢性炎症组织PI3K和caspase-3的表达水平。[结果]NPC组中PI3K的阳性率分别为86.7%(52/60)与60.9%(14/23)(P<0.05);caspase-3的表达率分别为48.3%(29/60)与73.9%(17/23)(P<0.05);NPC中,PI3K的表达强度与caspase-3的表达呈负相关(P<0.05)。[结论]PI3K/Akt/mTOR信号通路的激活可能通过某种机制抑制caspase-3的表达,进而减少肿瘤细胞的凋亡,这在鼻咽癌的发病中起一定的作用。
[Objective ] To investigate the effects of expressions of PI3 K and caspase - 3 on the tumorigenesis in nasopharyngeal carcinoma. [ Methods] Immunohistochemical method was used to examine expressions of PI3K and caspase -3 in 60 nasopharyngeal carcinomas （ groupl ） and 23 non - tumor nasopharyngeal tissues （group2）. [ Results] In group 1 and group 2, the expression rates of PI3K were 86.7% （52/60） and 60.9% （ 14/23 ） respectively, （ P 〈 0.05 ） ; While the rates of caspase - 3 were 48.3% （29/60） and 73.9% （17/23） respectively, （P 〈 0.05 ）. The expression of caspase- 3 was negatively correlated with that of PI3K in nasopharyngeal carcinoma （P 〈 0.05 ）. [ Conclusion ] The activation of PI3K/Akt/mTOR signaling pathway may inhibit the expression of caspase -3 to decrease apoptosis and promote proliferation of NPC cells.
出处
《大连医科大学学报》
CAS
2007年第2期120-121,共2页
Journal of Dalian Medical University
