摘要
目的测定并比较分析屏障环境和IVC饲养条件下SD大鼠的主要脏器重量及脏器系数的差异。方法用电子天平分别测定了30只在屏障环境中和IVC饲养条件下SD大鼠的心、肝、脾、肺、肾、肾上腺、子宫、睾丸和卵巢的重量及脏器系数。结果雄鼠之间比较,脾脏重量差异显著,其它各脏器系数间无显著性差异;雌鼠之间比较,各脏器重量间无显著性差异,肾脏系数差异显著(P<0.05);两种条件下,雄雌鼠之间脏器重量比较差异非常显著(P<0.01),IVC雄雌之间脏器系数比较,肝、肾间无显著性差异,其它差异非常显著;屏障条件下,雄雌之间脏器系数比较,心、脾、肺、肾上腺、脑差异显著(P<0.05),肾无差异。结论屏障环境和IVC条件下饲养的SD大鼠脏器重量及脏器系数间差异较小。
Objective To measure and analyze the main organ weight and coefficients of SD rats in a barrier system and individually ventilated cages. Methods Total 60 SD rats were used in this study,30 in each group. The rats were raised in a barrier system and IVC for 120 days. The main organ weight and coefficient for heart, liver, spleen, lung, kidney; adrenal, brian testis uterus, ovary were then measured using an electronic scales. Result between female SD rats, spleen weight showed significant difference（ P 〈 0.01）,all organ coefficients were no significant differences（ P 〈 0.05）; Between male SD rats, all organ weight were no significant difference （ P 〈 0.05 ）, kidney coefficient showed significant differences （P 〈 0.05） ; between female and male,in a barrier systems and IVC,all organ weight showed very significant differences（ P 〈 0.01）, between female and male in IVC, no differences were found in the liver and kidney coefficients （P 〈 0.05）; between female and male in close system, the organ coefficient of the heart, spleen, lung,adrenal and brain showed significant the difference （P 〈 0.05）. Conclusion The organ weight and coefficient of SD rats in a barrier system and IVC were not different significantly.
出处
《实验动物科学》
2007年第1期16-18,共3页
Laboratory Animal Science
关键词
屏障环境
IVC
脏器重量
脏器系数
Barrier system
Individually ventilated cage（IVC）
Organ weight
Coefficient of organ
