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T型钙通道及其作用药物研究进展 被引量：10

Research progress of T-type calcium channels and the related drugs
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摘要 T型钙通道广泛分布于心血管,神经和内分泌等系统,目前已成为药物靶点研究的热点。近年来编码T型钙通道的基因已被确定,它的重要功能也得到认识。许多药物可以非特异性的阻断T型钙通道。文章从分子结构、分布、功能、调控及作用药物等方面对T型钙通道目前的研究作一综述。 T-type calcium channels present in cardiovascular, neuronal and endocrine systems, and they are now receiving attention as novel therapeutic targets. It plays important roles in multiple cellular functions and genes those encode the T-type calcium channels have been recently reported. Many drugs and compounds non-specifically block T-type calcium channels. Wereview circumstances of the research of T- type calcium channels in the molecular structure, distribution, function, regulation and the related drugs.
作者 张志国 张庆柱
机构地区 山东大学药学院新药药理研究所
出处 《中国药理学通报》 CAS CSCD 北大核心 2007年第2期143-147,共5页 Chinese Pharmacological Bulletin
关键词 T型钙通道 分子结构 生理功能 药物作用 T-type calcium channel molecular structure physiological function drug effects
分类号 R-05 [医药卫生] R329.24 [医药卫生—人体解剖和组织胚胎学]
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参考文献26

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共引文献9

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中国药理学通报
2007年 第2期

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