摘要
观察小剂量氟尿嘧啶联合顺铂和醛氢叶酸治疗晚期胃癌的近期疗效、临床受益率及毒性反应。方法：采用小剂量氟尿嘧啶（350mg／m^2）联合顺铂（10mg／d）和醛氢叶酸（50mg／mz）静脉滴入，治疗晚期胃癌36例。根据患者不良反应尽量采取长程用药，全部患者均接受2～6个周期化疗，每个周期5～20d不等。结果；全组患者有效率（CR＋PR）44．4％，其中CR11．1％，PR33．3％，SD36.1％，PD19．4％。低分化腺癌、管状腺癌、乳头状腺癌、黏液细胞癌有效率分别为22．2％、13．9％、2．8％、0；临床受益率80．6％，食欲好转72．2％，疼痛减轻52．8％，体质量增加30．6％，Kamofsky评分增加〉20分为63．9％。不良反应主要为恶心、呕吐、外周静脉炎、口腔溃疡和白细胞减少，多为Ⅰ～Ⅱ度。结论：小剂量氟尿嘧啶联合顺铂和醛氢叶酸缓慢静脉滴入是治疗晚期胃癌的一种安全有效的化疗方案。
The objective of this study was to investigate the clinical response, benefit and safety of chemotherapy with low-dose of 5-FU in corabination with DDP and CF in the treatment of advanced gastric cancer patients. Methods： Low-dose of 5-FU （350 mg/m^2） in combination with DDP（10 mg/d） and CF（50 mg/m^2 ） was administered to 36 cases of advanced gastric cancer, and according to the difference of side reaction, the chemotherapy cycle was 5-20 days. Results： Thirty-six patients received 2-6 cycles of the chemotherapy. The total response rate was 44. 4%, including CR 11.1%, PR 33.3%, SD 36.1%, and PD 19.4%. The response rates of poorly differentiated adenocarcinoma, tubular adenocarcinoma, papillary adenocarcinoma and myxoblast adenocarcinoma were 22.2 %, 13.9 %, 2. 8 %, and 0, respectively. The clinical benefit rate was 80. 6%, appetite improved 72. 7%, pain lightened 52.8%, weight increased 30. 6%, and 63.9% of patients had more than 20 scores added in Karnofsky. The main untoward reactions were nausea, vomiting and neutropein, and most of them were Grade Ⅰ-Ⅱ. Conclusion： Chemotherapy with low-dose of 5-FU in combined with DDP and CF is effective and well tolerated in the patients with advanced gastric cancer.
出处
《中华肿瘤防治杂志》
CAS
2007年第2期146-147,共2页
Chinese Journal of Cancer Prevention and Treatment
关键词
胃肿瘤/药物疗法
氟尿嘧啶
顺铂
醛氢叶酸
gastric cancer
chemotherapy
fluorouracil
cisplatin
calcium folinate
