摘要
目的:观察多西他赛(docetaxel)联合顺铂(DDP)和氟尿嘧啶(5FU)方案(简称DCF方案)对进展期胃癌的近期疗效和毒副反应。方法:对经病理学或细胞学确诊的48例进展期胃癌患者,采用DCF方案化疗:多西他赛40mg/m2,静脉滴入1h,d1、d8、d15;DDP20mg/m2,静脉滴入,d1～d5;5FU750mg/m2用便携式微量输液泵持续静脉输注,d1～d5;28d为1个周期,至少2个周期评价疗效。结果:48例完全缓解(CR)3例,部分缓解(PR)22例,无变化(NC)16例,进展(PD)7例,总有效率(RR)为52.08%。其中初治组有效率为68.18%(15/22),有2例CR;复治组有效率为38.46%(10/26),有1例CR,两组差异有统计学意义,P=0.04。毒副反应主要为骨髓抑制、消化系统反应和脱发。大部分患者为Ⅰ、Ⅱ度反应,耐受良好。骨髓抑制为剂量限制性毒性,其中白细胞减少占64.58%,Ⅲ～Ⅳ度占16.67%。结论:多西他赛联合DDP和5FU治疗进展期胃癌具有近期疗效好,毒副反应轻,耐受好的特点,且初治者疗效优于复治者,值得进一步研究推广。
OBJECTIVE： To evaluate the efficacy and toxicity of docetaxel combined with cisplatin and fluorouracil in the treatment of patients with advanced gastric cancer. METHODS. Forty-eight patients with a advanced gastric cancer diagnosed pathologically were enrolled into the study. The patients received docetaxel 40 mg/m^2 on day 1, 8, 15; on day 1 to 5 infused with 5-FU 750 mg/m^2 using an ambula tory pump; and cisplatin 20mg/m^2 on day 1 to 5. The chemotherapy was repeated every 28 days. All the patients received at least 2 cycles. RESULTS： Objective response was obtained in 52.08%（25/48） of patients （3 complete and 92 partial responses ）, whereas 16 patients had no change and 7 patients were progressive. Significant difference existed between the naive patients and pretreated patients （68.18% vs 38.46%, P =0.04）. The main toxicities included myelosuppression, nausea,vomiting and alopecia. The serverities of these side effects were grade Ⅰ , Ⅱ and well tolerated. Myelosuppression was dose-limiting toxicity and hypolekocytosis was 64.58% in total. CONCLUSION： Doeetaxel combined with cisplatin and fluorouracil is effective in the treatment of advanced gastric cancer, with mild to moderate side effects.
出处
《肿瘤防治杂志》
2005年第23期1803-1805,共3页
China Journal of Cancer Prevention and Treatment
关键词
胃肿瘤/药物疗法
紫杉酚/投药和剂量
顺铂/投药和剂量
氟尿嘧啶/投药和剂量
stomach neoplasms/drug therapy
failtaxel/administration ＆ dosage
cisplatin/administration ＆ dos-age
fluorouracil/administration ＆ dosage
