摘要
目的探讨中国人群脂联素基因+276G/T位点多态性与2型糖尿病(T2DM)的相关性。方法检索2011年8月前中国知网、维普中文科技期刊全文数据库、中国万方数据库、中国学位论文全文数据库和中国重要会议论文全文数据库及Med-line、Cochrane Library、Embase、Springer、Ovid等数据库,收集有关中国人群脂联素基因+276G/T位点多态性与T2DM相关性研究的文献;评价纳入研究质量,提取有效数据,采用Review Manager5.0软件进行Meta分析。结果共纳入11项研究中国人群脂联素基因+276G/T位点多态性与T2DM相关性的病例对照研究;T2DM患者1697例,健康对照者1341例。Meta分析结果显示,脂联素基因+276G/T位点G/T多态性与T2DM的相关性中T等位基因与G等位基因(OR=0.83,95%CI为0.65～1.05,P=0.12)、基因型(GT+TT)与GG(OR=0.82,95%CI为0.60～1.12,P=0.20)、基因型GT与GG(OR=0.93,95%CI为0.63～1.38,P=0.72)、基因型TT与GG(OR=0.81,95%CI为0.46～1.42,P=0.46)比较,差异均无统计学意义。结论中国人群脂联素基因+276G/T位点多态性可能与T2DM易感性无关。
Objective To investigate the association between the polymorphism of adiponectin gene＋276G/T site and type 2 diabetes mellitus（T2DM） in Chinese population.Methods Literatures,related with correlation research on adiponectin gene polymorphism ＋276G/T site and T2DM in Chinese population,were retrieved in databases including CNKI,VIP,Wanfang Database,CDDB,CPFD,Medline,Cochrane Library,Embase,Springer and Ovid before August 2011.The quality of enrolled researches was evaluated and valid data were extracted.Meta analysis was performed by using Review Manager 5.0 software.Results Eleven case-control researches on correlation between adiponectin gene ＋276G/T site polymorphism and T2DM in Chinese population were enrolled,involving 1 697 patients with T2DM and 1 341 controls.Meta analysis indicated that,according to the correlation with T2 DM,there was no statistical difference between T allele and G allele（OR=0.83,95%CI for 0.65-1.05,P=0.12）,genotype of（GT＋TT） and GG（OR=0.82,95%CI for 0.60-1.12,P=0.20）,genotype of GT and GG（OR=0.93,95%CI for 0.63-1.38,P=0.72）,and genotype of TT and GG（OR=0.81,95% CI for 0.46-1.42,P=0.46）.Conclusion Adiponectin gene＋276G/T site polymorphism might be not associated with T2DM in Chinese population.
出处
《国际检验医学杂志》
CAS
2012年第10期1172-1174,共3页
International Journal of Laboratory Medicine
关键词
脂联素
基因
糖尿病
2型
META分析
中国
人口
adiponectin； genes； diabetes mellitus,type 2； meta-analysis； china； population；
