摘要
目的评价头孢哌酮/舒巴坦与左氧氟沙星(组1)、多黏菌素B与利福平(组2)联合应用,对43株多重耐药铜绿假单胞菌的体外抗菌效应。方法采用琼脂稀释法测定抗菌药物单独应用和最佳组合效应时的MIC值,计算部分抑菌浓度(FIC)指数,判定联合抑菌效应。结果头孢哌酮/舒巴坦与左氧氟沙星、多黏菌素B与利福平联合应用后对铜绿假单胞菌的MIC均有显著降低(P<0.01),根据FIC指数分布,表现协同作用的分别为65.1%和93.0%;相加作用的分别为32.6%和7.0%;无关作用的分别为2.3%和0;无拮抗作用。结论头孢哌酮/舒巴坦与左氧氟沙星、多黏菌素B与利福平联合应用,对多重耐药铜绿假单胞菌的体外抗菌作用以协同和相加为主,特别是多黏菌素B与利福平联合应用显示了良好的协同作用。
OBJECTIVE To investigate the combined effect of cefoperazone/sulbactam with levofloxacin（group 1） and polymyxin B with rifampin （group 2） on 43 isolates of multi-drug-resistant Pseudomonas aeruginosa. METHODS The minimal inhibitory concentration（MIC） of all the antibiotics mentioned above was determined by agar dilution method. Fractional inhibitory concentration（FIC） index was calculated for all the selected isolates with all combinations, and the activities of antibiotics alone and in combination against the selected strains were evaluated. RESULTS The MIC of all the combined antimicrobials was reduced significantly（P〈0.01）. Of 43 isolates, 28（65. 1%）and 40（93%） revealed synergy, 14（32. 6%） and 3（7%） showed addition; 1（2.3%） and 0 （0%）exhibited indifference, respectively, according to the result of the FIC index assay. Both of the two groups showed no antagonism. CONCLUSIONS The activities of levofloxacin combined with cefoperazone/sulbactam, or polymyxin B with rifampin are mainly synergistic and additive.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2007年第2期210-212,共3页
Chinese Journal of Nosocomiology
关键词
铜绿假单胞菌
最低抑菌浓度
抑菌浓度
抗菌药物
Pseudomonas aeruginosa
Minimal inhibitory concentration（MIC）
Fractional inhibitory concentration （FIC）
Antibiotics
