摘要
目的 调查湖北地区临床分离菌对抗菌药物的耐药状况。方法 将湖北地区 15所医院纸片扩散法药敏试验的抑菌环直径输入计算机 ;根据 1999年 NCCL S颁布的准则 ,采用“WHONET- 5”软件完成统计分析。结果 临床分离菌中革兰阳性球菌有增多趋势 ;金黄色葡萄球菌 (金葡菌 )、大肠埃希菌、铜绿假单胞菌和凝固酶阴性葡萄球菌 (CNS)最常见 ;31.0 %金葡菌和 6 7.6 % CNS对苯唑西林耐药 ,对其他药物的耐药率也高 ;亚胺培南、头孢他啶、阿米卡星和环丙沙星对革兰阴性杆菌 (包括肠杆菌科细菌和非发酵菌 ) ,有良好的抗菌活性 ,但与 1996年监测资料比较 ,敏感率均在显著下降。结论 临床细菌耐药性日益严重 ,应在不同地区开展细菌耐药性监测 ;
OBJECTIVE To study the resistance of clinical bacterial isolates in Hubei area. METHODS The diameters of the inhibition zone of clinical isolates around antibiotic susceptibility test disks at 15 hospitals were computer filed and analysed by the software of 'WHONET-5' according to NCCLS published in 1999. RESULTS The number of Gram-positive cocci was increasing in clinical isolates. Staphylococcus aureus, Escherichia coli, Plasmonas aeruginosa and coagulase negative staphylococci (CNS) were the main microorganisms. Thirty one percent of S.aureus and 67.6% of CNS were resistant to oxacillin and other antimicrobials. Imipenem, ceftazidime, amikacin and ciprofloxacin were the most active agents against Gram-negative organisms including Enterobacteriaceae and glucose nonfermenters, while the susceptible rates were significanfly lower be compared with the data in 1996. CONCLUSIONS It is suggested that there be an urgent need for surveillance of bacterial resistance in different districts and rational use of antimicrobial agents be emphasised during clinical therapy.
出处
《中华医院感染学杂志》
CAS
CSCD
2002年第2期91-93,101,共4页
Chinese Journal of Nosocomiology
关键词
抗药性
微生物
细菌
药物监测
湖北
Drug
Resistance
Microbe
Bacteria
Drug monitoring
