摘要
目的对比卡维地洛与美托洛尔两种不同类型的β-受体阻滞剂对高血压心脏病患者心室重塑的影响。方法将63例高血压心脏病患者在常规心衰治疗基础上随机分为卡维地洛组(A组,n=32)和美托洛尔组(B组n=31),应用超声心动图分别于治疗前、治疗6个月、治疗12个月后测量室间隔厚度(IVS)、左室后壁厚度(IVPW)、左室重量指数(LVMI)、左室球径指数(LVGI)。结果①治疗6个月时,两组LVMI、LVGI较治疗前明显减少,A组较B组减少更显著。②治疗12个月后两组IVS、IVPW、LVMI、LVGI均较治疗前显著改善;A组与B组比较,LVPW、LVMI、LVGI差异有显著性。结论卡维地洛在改善心室重塑方面较美托洛尔更显著,治疗时间达一年时,卡维地洛的这种优势将更显著。
Objective To compare the different influence on ventrlcular remodeling of β-blockers carvidilol and metrolol in hypertensive heart disease patients. Methods 63 cases of hypertensive heart disease patients were divided into two groups randomly, besides the normal medicine, one group was given carvidilol （ Group A, n = 32）, while the other group was given metrolol （ Group B, n = 31 ）. Ventricular remodeling was calculated by measuring interventricular septum（ IVS）, left ventricular post wall（ LVPW）, left ventricular weight index（LVWI） and left ventricular global-diameter index（LVGI） with ultrasonic cardiograph in the beginning and after 6 months and 12 months of the treatment. Result①6 months after the treatment, LVMI, LVGI desereased significantly, especially in group A. ②After 12 months of treatment, IVS, LVPW, LVMI, LVCI were all improved significantly , with the improvement more significant in group A. Conclusion Carvidilol shows superiority than metrolol in improving ventrieular remodeling in the treatment of hypertensive heart disease patients,and this benefit increases when it is used for a period of one year.
出处
《内科》
2007年第1期3-5,共3页
Internal Medicine
关键词
高血压心脏病
卡维地洛
美托洛尔
心室重塑
Hypertensive heart disease
Carvidilol
Metrolol
Ventrieular remodeling
