摘要
目的 结合动态血压监测（ABPM）方法评价卡维地洛与美托洛尔对轻、中度高血压的降压效应。方法 高血压患者78例随机分为卡维地洛组（n=39）和美托洛尔组（n=39）。分别给予卡维地洛（25～50mg／d，1次／d）和美托洛尔（100～200mg／d，2次／d），治疗12周。观察服药前及服药后12周末的24h、白昼、夜间及各时点的动态血压变化及谷／峰比。结果 卡维地洛组和美托洛尔组服药前、服药治疗后12周末的24h、白昼、夜间的平均收缩压、舒张压明显下降，有显著性差异（P＜0．05或＜0．01）。卡维地洛组服药后12周末各时点收缩压、舒张压较服药前明显下降，有显著性差异（P＜0．05）。美托洛尔组服药后12周末各时点收缩压、舒张压较服药前下降，但服药后的第23～24h夜间血压下降不明显（P＞0．05）。两组治疗后平均收缩压（SBP）和平均舒张压（DBP）的谷／峰比（T／P值）分别是63％／57％，和59％／51％。结论 卡维地洛可维持24h平稳降压；美托洛尔仅能维持22h内血压下降；两者均有满意的谷／峰比。
Objective To compare the clinical efficacy of two β-adrenoceptor antagonists（carvedilol and metoprolol） in the treatment of essential hypertension using ambulatory blood pressure monitoring（ABPM）. Methods Seventy-eight patients with essential hypertension were enrolled in the study. The patients were randomly assigned to receive carvedilol group（25-50 mg/d, n=39） and metoprolol group（ 100-200 mg, Bid, n=39） for 12 weeks. 24 h blood pressure, day time and night time BP, every time point of 24 h ABPM, as well as T/P ratios before and after 12 weeks treatment were determined. Results At the end of the 12 week, the mean systolic blood pressure SBP/DBP of 24 h, day time and night time were decreased markedly in two groups. In carvedilol group SBP/DBP were decreased at every time point of 24 h ABPM. In metoprolol group although SBP/DBP were also decreased at most time points, but not significant between 23-24th hour after the usage of medication（ P〉0.05）. The mean trough/peak ratio in carvedilol group and metoprolol group for SBP was 63% and 57%, DBP was 59 % and 51%. Conclusion Although good trough/peak ratio has been shown in both carvedilol and metoprolol, carvedilol （25-50 mg/d） reduced blood pressure smoothly for 24 h, while metoprolol （100-200 mg, Bid） could keeps the decreased BP for only 22 h in some Patients.
出处
《中华高血压杂志》
CAS
CSCD
北大核心
2006年第9期735-738,共4页
Chinese Journal of Hypertension
关键词
卡维地洛
美托洛尔
动态血压监测
Carvedilol
Metoprolol
Ambulatory blood pressure monitoring
