摘要
目的:观察野百合碱(crotaline)诱导慢性肺损伤的病理变化及探讨肺动脉高压形成机理。方法:24只SD大鼠一次性皮下注射crotaline 50 mg/kg体重,建立肺动脉高压动物模型。通过光学显微镜观察crotaline对肺动脉血管内皮细胞的损伤和肺部的病理改变,并分析病变之间以及它们与肺动脉高压的关系。结果:注射crotaline可使肺动脉血管内皮细胞损伤,并诱导肺动脉平滑肌明显增生,导致肺动脉血管壁的重建和右心室肥厚。结论:肺动脉血管壁的重建是肺动脉高压的主要病理基础。
Objective： To observe the pathological changes of chronic injury of lungs and explore the mechanism of pulmonary arterial hypertension（PAH） development. Methods： PAH was induced in ten rats by a single subcutaneous injection of crotaline at a dose of50 mg/kg. Lung sections （HE stained） were observed under light microscope for pathological changes and damages of vascular endothelial cells of the pulmonary arteries. Their relationship with PAH was analyzed. Results： Damages in vascular endothelial cells of pulmonary arteries of rats received crotaline injection were observed and showing as hyperplasy of smooth muscle and right ventricular hypertrophy. Conclusion： Rebuilding of the structure in pulmonary arterial after the damage might be the pathological basis of PAH.
出处
《贵阳医学院学报》
CAS
2007年第1期1-4,共4页
Journal of Guiyang Medical College
基金
国家自然科学基金资助项目(编号30560159)
教育部新世纪优秀人才支持计划项目(NCET-05-0820)
