摘要
目的测定老年肺心病患者血浆内皮素（ＥＴ）、心钠素（ＡＮＰ）水平及探讨其临床意义。方法用放射免疫法测定健康老年人、非老年肺心病及老年肺心病患者各３０例不同时期血浆ＥＴ及ＡＮＰ水平。结果老年肺心病患者急性加重期及缓解期ＥＴ分别为３０４±８３及１３２±４１ｐｇ／ｍｌ，ＡＮＰ分别为３１９±９０及２３５±８４ｎｇ／ｍｌ，较健康对照组明显升高（Ｐ值＜０．０１或０．００１）。肺心病合并Ⅱ型呼吸衰竭者ＥＴ、ＡＮＰ分别为３８４±６６及３８４±７８ｎｇ／ｍｌ，明显高于合并Ⅰ型呼吸衰竭者（Ｐ值＜０．０５）。同期测定的３０例非老年肺心病患者血浆ＥＴ与ＡＮＰ水平与老年患者差异无显著性（Ｐ值＞０．０５）。直线相关分析表明，血浆ＥＴ与ＡＮＰ之间无显著性相关性。结论肺心病患者血浆ＥＴ、ＡＮＰ含量增高可能参与疾病的发生与发展过程，但在肺心病情况下。
Objecitve To determine the levels of plasma endothelin(ET) and atrial natriuretic peptide(ANP) in aged patients with cor pulmonale at different stages and to reveal the relationship between ET and ANP.Methods The levels of plasma ET and ANP were measured by radioimmunoassay at different stages in 30 elderly and 30 non-elderly patients with cor pulmonale and 30 aged healthy persons.Results The results showed that plasma ET and ANP levels in patients with cor pulmonale were significantly higher than those in the healthy.The concentration of plasma ET at acute exacerbation stage and remission stage was 304±83pg/ml(P<0.001) and 132±41pg/ml(P<0.01)respectively.The levels of plasma ANP at acute exacerbation and remission was 319±90pg/ml(P<0.001) and 235±84pg/ml(P<0.01) respectively. Plasma ET and ANP levels in patients with type Ⅱ respiratory failure were significantly higher than those with type Ⅰrespiratary failure (P<0.05).Conclusions It is suggested that the elevation of ET and ANP levels may contribute to the pathophysiological changes in patients with cor pulmonale;but the relationship between ET and ANP in the same patients remains unclear.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
1996年第3期137-139,共3页
Chinese Journal of Geriatrics
关键词
肺心病
血液
内皮素
钠利尿肽类
pulmonale heart disease endothelin natriuretic peptide,atrial
