摘要
目的:探讨信号转导和转录激活因子3(STAT3)及磷酸化STAT3(P-STAT3)在喉癌组织中的表达情况及活化STAT3蛋白表达与喉癌临床病理特征的关系。方法:用免疫组织化学法检测50例手术切除的喉癌组织(喉癌组)和10例癌旁正常组织(对照组)中STAT3及P-STAT3蛋白的表达。结果:喉癌组中有36例(72.0%)STAT3蛋白表达阳性,29例(58.0%)P-STAT3蛋白表达阳性,对照组均为阴性表达(均P<0.01)。STAT3主要表达在细胞质,P-STAT3主要表达在细胞核内;STAT3及P-STAT3在低分化、临床分期较晚和有淋巴结转移的喉癌患者中阳性表达率高(P<0.05或P<0.01)。结论:喉癌组织中存在STAT3和P-STAT3的高表达,并与临床病理分期和淋巴结转移有关;STAT3的表达可作为判定喉癌生物学行为的一个指标。
Objective：To investigate the expression of STAT3 and P-STAT3 and the relationship between P- STAT3 and various clinical pathological characteristics in human laryngeal carcinoma. Method： The expression of STAT3 and its activated form P-STAT3 in tumor tissues from 50 radically resected specimens of laryngeal carcinoma and 10 normal laryngeal tissues was detected by immunohistochemical staining. Result：The rate of protein expression of STAT3 and P-STAT3 in laryngeal carcinoma were 36/50 （72.0 % ） and 29/50 （58.0 % ） respectively, which were significantly higher than that in normal group（ P 〈0.01）. The positive rate of P-STAT3 was closely related to the clinical stage and lymph node metastasis（ P 〈0.05）. The expression STAT3 in laryngeal carcinoma was located in the cytoplasm of carcinoma cells, while P-STAT3 was located in the cell nucleus. Conclusion：STAT3 and PSTAT3 were overexpressed in human laryngeal carcinoma. Activation of STAT3 was significantly related to the clinical stage and lymph node metastasis. The expression of STAT3 can be used as a significant parapreter in predicting the biological behaviour of largngeal carcinoma.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2007年第3期113-115,共3页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
