摘要
喉癌的发生、发展受多种基因的调控,信号转导及转录活化因子3(STAT3)和血管内皮生长因子(VEGF)在喉癌的发生、发展、转移及预后中起重要作用。STAT3由细胞外细胞因子、生长因子等多肽类配体激活,作用于细胞核内特异的DNA片段,调控靶基因的转录,促进细胞的增殖、抑制凋亡。肿瘤的生长依赖肿瘤新生血管的形成,VEGF是重要的血管生成正性调节因子,所以对STAT3和VEGF的一些相关性研究为喉癌发生、发展机制的阐述奠定了基础。
The occurrence and progress of laryngeal neoplasms are regulated by many genes,signal transducers and activators of transcription 3（STAT3）and VEGF plays important roles in the occurrence,progress,metastasis and prognosis of laryngeal neoplasms.STAT3 is activated by extracellular ligands,including cytokines and growth factors.It can translocate to nucleus,where it binds to specific DNA sequences and regulates the transcription of target genes,and promotes the proliferation and inhibits apoptosis of tumor cells.Tumor growth relies on angiogenesis,VEGF plays an important role in angiogenesis as a positive regulatory factor.So some studies about the STAT3 and VEGF are carried out to establish foundation for genesis mechanism of human laryngeal cancer.
出处
《医学综述》
2012年第9期1319-1322,共4页
Medical Recapitulate
关键词
信号转导及转录活化因子3
血管内皮生长因子
喉癌
Signal transducers and activators of transcription 3
Vasculal endothelial growth factor
Laryngeal cancer
