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血红素氧合酶-1/一氧化碳系统与急性肺损伤 被引量：1

Heme Oxygenase-1/Carbon Monoxide and Acute lung injury
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摘要 血红素氧合酶-1/一氧化碳(HO-1/CO)系统在多种应激状态下诱导产生,通过抗氧化、抗炎、抗凋亡等机制发挥组织器官保护作用,基因治疗、药物诱导HO-1高表达或外源性CO可能成为治疗多种疾病的新途径。本文就HO-1/CO系统的产生、调控及在急性肺损伤中的表达和作用简要综述。 Heine Oxygenase-1/Carbon Monoxide system （HO-1/CO） is induced by various stimuli and stresses, which exerts cytoprotection through antioxidation, antiinflammatory and antiapoptosis. Upregulation of HO- 1 through gene therapy and pharmacological induction as well as exogenous carbon monoxide may provide new way for future disease therapy.This article summarize HO-1/CO about its production,regulation and its expression and effect in acute lung injury.
作者 安莉 俞森洋
机构地区 中国人民解放军总医院南楼呼吸科
出处 《医学综述》 2007年第3期163-165,共3页 Medical Recapitulate
关键词 急性肺损伤 血红素氧合酶-1 一氧化碳 胆红素 Acute lung injury Heine Oxygenase-1 Carbon Monoxide Bilirubin
分类号 R563 [医药卫生—呼吸系统]
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参考文献21

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二级参考文献7

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医学综述
2007年 第3期

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