摘要
目的对地红霉素肠溶片释放度测定的三种方法进行系统的研究和比较,并建立其最佳测定方法。方法分别采用口占吨氢醇显色法、硫酸显色法以及高效液相色谱法测定地红霉素肠溶片的释放度,对每种方法进行方法学的研究和验证。结果采用三种方法均可以准确地测定地红霉素肠溶片的释放度,不同方法测得结果差异较小。结论硫酸显色法因试剂易得,操作简便,快捷、准确,将其作为最佳测定方法。
Objective Three methods by which the release of dirithromycin enteric-coated tablets were determinated and compared. Methods Xanthydrol coloring method, sulfuric acid coloring method, and HPLC method were developed for determination of the release of dirithromycin enteric-coated tablets. Result All of these methods can be used to determine the samples precisely, and difference of the results among them is slightly. Conclusion Sulfuric acid coloring method is inexpensive, simple, rapid and precise, and it is regarded as the optimal method.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2007年第2期91-94,共4页
Chinese Journal of Antibiotics
关键词
地红霉素
肠溶片
释放度
Dirithromycin
Enteric-coated tablets
Release
