期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

中枢神经损伤再生修复去抑制作用的研究 被引量：9

Research development on disinhibition of the regeneration after CNS injury
暂未订购
导出
摘要 中枢神经损伤后,由于其所处微环境存在多种轴突生长抑制因子,它们主要通过细胞膜上一个复合受体将抑制信息传递至细胞内,导致生长锥塌陷,轴突生长受到抑制。据此,人们设计了各种方法去除轴突再生时的抑制作用。本文简要的介绍了这些研究。 Axons in the adult central nervous system （CNS）are unable to regenerate after injury due to the growth-inhibitory proteins present in CNS myelin. Inhibitors signal through a common receptor complex in neurons caused collapse of the growth cone and prevent axon growth. Based on these, there are plenty of researches on disinhibition of axon regeneration. This review focused on these researches.
作者 尹小磊 叶剑 陈春林
机构地区 第三军医大学大坪医院野战外科研究所眼科
出处 《国际眼科杂志》 CAS 2007年第1期154-156,共3页 International Eye Science
基金 中国国家自然科学基金资助项目(No.30572009) 中国重庆市科委自然科学基金资助项目(No.2005BB5273)~~
关键词 中枢神经系统 损伤 再生 去抑制作用 CNS injury regeneration disinhibition
分类号 R651.3 [医药卫生—外科学]
  • 相关文献

参考文献48

  • 1Liu BP, Foumier A, GrandPre T, Strittmatter SM. Myelin associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science,2002;297:1190-1193.
  • 2McKerracher L, David S, Jackson DL, Kottis V, Dunn P,J, Braun PE. Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth. Neuron,1994;13:805-811.
  • 3Mukhopadhyay G, Doherty P, Walsh FS, Crocker PR, Filbin MT. A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration.Neurom,1994;13:757-767.
  • 4Wang KC, Kopfivica V, Kim JA, Sivasankaran R, Guo Y, Neve RL, He Z. Oligo-dendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth, Nature,2002;417:941-944.
  • 5Niederost BP, Zimmermann DR, Sc, hwab ME, Bandflow CE.Bovine CNS myelin contains neurite growth-inhibitory activity associated with chondroitin sulfate proteoglyeans.J Neurosci,1999;19:8979-8989.
  • 6Chen MS, Huber AB, van der Haar ME, Frank M, Schnell L, Spillmann AA,Christ F, Schwab ME. Nogo-A is a myelinassociated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature,2000;403:434-439.
  • 7Prinjha R, Moore SE, Vinson M, Blake S, Morrow R, Christie G, Michalovich D,Simmons DL, Walsh FS. Inhibitor of neurite outgrowth in humans. Nature,2000;403:383-384.
  • 8叶剑,王正国,朱佩芳.Nogo-A mRNA在大鼠神经组织中的表达和定位[J].中华医学杂志,2002,82(7):498-500. 被引量：24
  • 9叶剑,王正国,朱佩芳,彭锡嘉.视神经损伤后Nogo-A mRNA表达的变化[J].中华眼底病杂志,2003,19(4):247-249. 被引量：9
  • 10Wang KC, Kim JA, Sivasankaran R, Segal R, He Z. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature,2002;420:74-78.

二级参考文献65

  • 1Berry M, Carlile J, Hunter A, Tsang W, Rosustrel P, Sievers J. Optic nerve regeneration after intravitreal peripheral nerve implants: trajectories of axons regrowing through the optic chiasm into the optic tracts. J Neurocy,1999;28:721-741
  • 2Faber-Elman A, Solomon A, Abraham JA, Marikovsky M, Schwartz M.Involvement of wound-associated factors in rat brain astrocyte migratory response to axonal injury: in viro simulation. J Clin Invest, 1996;97(1):162-171
  • 3Bahr M, Przyrembel C. Myelin from peripheral and central nervous system is a nonpermissive sulstrate for retinal ganglion cell axons. Exp Neurol,1995;134(1): 87-93
  • 4Schwab ME. Myelin-associated inhibitors of neurite growth and regeneration in the CNS. Trends Neurolsci, 1990;13(11):452-456
  • 5Bandtlow C, Zachleder T, Schwab ME. Oligodendrocytes arrest neurite growth by contact inhibition.J Neurosci, 1990;10(12):3837-3848
  • 6Niederost BP, Zimmermann DR, Schwab ME, Bandtlow CE. Bovine CNS myelin contains neurite growth-inhibitory activity associated with chondroitin sulfate proteoglycans. J Neurosci, 1999; 19(20):8979-8989
  • 7Wong Ev, David S, Jacob MH, Jay DG. Inactivation of myelin-associated glycoprotein enhances optic nerve regeneration. J Neurosci, 2003;23(8):3112-3117
  • 8Wunderlich G, Stichel CC, Schroeder WO, Muller HW. Transplants of immature astrocytes promote axonal regeneration in the adult rat brain. Glia,1994;10(1):49-58
  • 9Bahr M, Przyrembel C, Bastmeyer M. Astrocytes from adult rat optic nerves are nonpermissive for regenerating retinal ganglion cell axons. Exp Neurol, 1995;131(2):211-220
  • 10Fawcett JW, Housden E, Smith-Thomas L, Meger RL. The growth of axons in three dimensional astrocyte cultures. Dev Biol, 1989;135:449-458

共引文献45

同被引文献163

引证文献9

二级引证文献21

国际眼科杂志
2007年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部