摘要
目的探讨谷胱甘肽Ｓ－转移酶，Ｃ－ｅｒｂＢ－２在转移性非小细胞肺癌的表达及意义。方法用免疫组织化学技术对６０例非小细胞肺癌及淋巴结转移灶进行检测。结果肺癌淋巴结转移组原发灶ＧＳＴ－π阳性率５０％和Ｃ－ｅｒｂＢ－２阳性率６８％，转移淋巴结ＧＳＴ－π阳性率６５．５％，Ｃ－ｅｒｂＢ－２阳性率７１％。肺癌淋巴结未转移原发灶ＧＳＴ－π阳性率２８．５％，Ｃ－ｅｒｂＢ－２阳性率５７％。其中ＧＳＴ－π和Ｃ－ｅｒｂＢ－２均表达阳性者占４２％。结论ＧＳＴ－π和Ｃ－ｅｒｂＢ－２二者均可能参与肿瘤的侵袭转移过程，二者的阳性表达呈正相关。
Objective
To investigate the expression of GSTand CerbB2 in metastic NSCLC. Methods GST and CerbB2
were examined in patients with NSCLC and lymphnodes involvement by immunohistochemical
staining. Results The expressive rates of GST and CerbB2 in NSCLC were 50% and 68%
respectively, and in those with lymphnodes metastasis were 45.6% and 71% respectively. In
those without lymphnode metastasis,the expressive rates of GST and CerbB2 were 28.5 and
57% respectively.Conclusion GST and CerbB2 may take part in the process of NSCLC
metastasis and there is a positive relationship in GST and CerbB2 expression.
出处
《肿瘤研究与临床》
CAS
1999年第3期155-156,共2页
Cancer Research and Clinic
