摘要
目的探讨高血压病患者大动脉僵硬度对左室重构及功能的影响。方法应用脉搏波速度自动测量系统测量颈动脉-股动脉脉搏波速度(carotid-femoralpulsewavevelocity,CFPWV)和颈动脉-桡动脉脉搏波速度(carotid-radialpulsewavevelocity,CRPWV)分别作为反映中央弹性大动脉和外周中等肌性动脉僵硬度的指标,对36例正常人和246例高血压患者进行脉搏波速度及超声心动图检测,并根据左室质量指数(LVMI)和相对室壁厚度(RWT)将高血压患者分为左室正常和异常构型组。结果高血压左心室异常构型者CFPWV显著高于正常构型者(P<0.01),均高于正常对照组(P分别为<0.01和<0.05),CRPWV3组比较无显著差异(P>0.05)。CFPWV与RWT(r=0.133,P=0.028)、LVMI(r=0.122,P=0.044)、E/A(r=-0.313,P<0.001)及ETVI/ATVI(r=-0.345,P<0.001)呈显著相关关系,与反映收缩功能的指标无显著相关关系(P均>0.05),CRPWV与上述指标均无显著相关关系。多元逐步回归分析显示,CFPWV是影响RWT(标准化系数Beta=0.182,P=0.002)和E/A(标准化系数Beta=-0.216,P<0.001)的主要因素。结论高血压病患者大动脉僵硬度增加与左室重构及舒张功能减退密切相关。
Objective To explore the effects of large artery stiffness on left ventricular remodeling and function in patients with essential hypertension. Methods Automatic pulse wave velocity （PWV） measuring system was applied to examine carotid-femoral PWV （CFPWV） and carotid-radial PWV （CRPWV） as the parameters reflecting central elastic large arterial and peripheral muscular medium-sized arterial elasticity respectively. 246 untreated hypertensive patients and 36 healthy subjects were recruited in the study. Echocardiography was underwent to evaluate cardiac structure and function, and hypertensive patients were divided into left ventricular normal geometry group and left ventricular remodeling group according to left ventricular mass index （LVMI） and relative wall thickness （RWT）. Results CFPWV was higher in hypertensive patients with left ventricular remodeling than that in age-and gender-matched patients with left ventricular normal geometry （P〈 0.01） or healthy subjects （P〈0.05）. CFPWV, but not CRPWV had significant correlations with RWT （r=0. 133, P= 0.028）, LVMI （r=0. 122, P=0. 044）, E/A ratio （r= -0. 313, P〈0. 001） and ETVI/ATVI （r= -0. 345, P〈0. 001）. A stepwise multiple regression analysis demonstrated that CFPWV was significantly and independently related with E/A ratio （Beta=-0. 216, P〈0. 001） and RWT （Beta=0. 182, P=0. 002）. Conclusion Elevated large arterial stiffness has a close relationship with left ventricular remodeling and decreased diastolic function in patients with essential hypertension.
出处
《中国医学影像技术》
CSCD
北大核心
2006年第12期1838-1841,共4页
Chinese Journal of Medical Imaging Technology
关键词
高血压
动脉僵硬度
脉搏波速度
左室重构
左室功能
Hypertension
Artery stiffness
Pulse wave velocity
Left ventricular remodeling
Left ventricular function
