摘要
目的探讨曲美他嗪对高血压病患者炎性因子及动脉弹性功能的影响。方法 147例高血压病患者随机分为曲美他嗪治疗组(n=73),对照组(n=74)。均测量血压、检测血脂、高敏C反应蛋白(hs-CRP)、白介素6(IL-6)等血液指标。应用脉搏波速度自动测量系统进行颈动脉-股动脉脉搏波速度(CFPWV)检测,治疗6个月后再次测量上述指标。结果两组血压达标率无差异(67.6%vs 65.7%,P>0.05),其中CFPWV,hs-CRP、IC-6较治疗前明显降低(P<0.05)。与对照组相比,治疗组CFPWV,hs-CRP、IC-6,降低更显著。结论曲美他嗪通过抗炎作用可以改善高血压病患者的动脉弹性。
Objective To discuss the effects of trimetazidine on inflammatorycytokines and arterial elasticity of hypertensive patients. Methods 147 patientssuffered fromhypertension were randomlydivided into trimetazidine group（ n = 73） and control group（ n = 74）. Blood pressure,blood lipids,high sensitive C reactive protein（ hs-CRP） and interleukin-6（ IL-6） of all the patients were tested. And automatic pulse wave velocity system was used to test the carotid-femoral pulse wave velocity（ CFPWV）. All the above indexes were tested again after treatment for 6 months. Results Thedifference of blood pressure between the two groups was no statistically significant（ 67. 6% vs 65. 7%,P 0. 05）. CFPWV,hs-CRP and IL-6 of both groupreduced markedly after treatment（ P 0. 05）. Compared to control group,CFPWV,hs-CRP,and IL-6 of the treatmentgroupreduced more than the control group（ P 0. 05）. Conclusions Trimetazidine could improve thearterial elasticity of hypertensive patientsthroughreducing inflammatory cytokines.
出处
《齐齐哈尔医学院学报》
2014年第3期322-324,共3页
Journal of Qiqihar Medical University
关键词
曲美他嗪
炎性因子
脉搏波传导速度
高血压病
Trimetazidine
Inflammatory cytokines
Pulse Wave Velocity
Hypertension
