摘要
幽门螺杆菌(Helicobacter pylori,Hp)是导致人类慢性胃炎和胃溃疡的重要病原体,也是胃癌发生、发展过程中的重要起始因素。其中胃上皮细胞的增殖与凋亡的失衡,在胃癌发生、发展过程中起着决定性的作用,而Bc l-2家族对细胞凋亡的调控,在胃癌发生中又有着重要的意义。该文就幽门螺杆菌感染、细胞凋亡和Bc l-2家族调控机制的研究进展作一综述。
Helicobacter pylori is an important pathogen causing the human chronic gastritis and peptic ulcer, and it is a preliminary agent of the formation and development of gastric adenocarcinoma, while the imbalance of proliferation and apoptosis in gastric epithelial cell plays a decisive role in the process, In addition, the regulation of apoptosis by Bcl - 2 family is significant to this process. In this article, we discuss the research progress of the infection induced by H. pylori, apoptosis and regulation mechanism of Bcl -2 family.
出处
《嘉兴学院学报》
2006年第6期118-121,共4页
Journal of Jiaxing University
基金
嘉兴市科技计划资助项目(2006AY2044)
关键词
细胞凋亡
Bel-2家族
幽门螺杆菌
胃癌
apoptosis
Bcl - 2 family
helicobacter pylori
gastric adenocarcinoma.
