摘要
采用免疫组织化学方法检测７４例大肠癌中ｎｍ２３－Ｈ１、ｐ５３、ＰＣＮＡ以及ＩＶ型胶原的表达情况，以研究大肠癌中ｎｍ２３－Ｈ１、ｐ５３、ＰＣＮＡ的表达意义及与肿瘤浸润转移的关系。结果：大肠癌中ｎｍ２３－Ｈ１、ｐ５３、ＰＣＮＡ的阳性率分别为７１．６％、５２．７％、８１．１％。ｎｍ２３－Ｈ１低表达与淋巴结转移有关（Ｐ＜０．０５），在ＩＶ型胶原表达不同的肠癌中ｎｍ２３－Ｈ１的表达无明显差异；ｐ５３、ＰＣ－ＮＡ过表达与浸润程度和淋巴结转移有关（Ｐ＜０．０５）。表明：ｎｍ２３－Ｈ１低表达仅作用于大肠癌的转移过程，可作为预测大肠癌转移的较好指标。ｐ５３过表达在浸润转移过程及细胞增殖中均起重要作用。
To study the relation between the expression of nm23-H1,p53,PCNA andinfiltration as well as metastasis of human carcinoma of large intestine,the nm23-H1,p53,PCNA and IV collagen has been tested in 74 patients with large intestinal carcinoma throughimmunohistochemical technique. Results:The positive expression for nm23-H1,p53 and PC-NA was 71.6%,52.7%and 81.8%respectively. A low expression of nm23-H1 was relatedto metastasis of lymph nodes(P<0.05).No significant difference in those with different ex-pression of IV collagen. Meanwhile,a significant correlation were found between p53,PCNAover-expression and the degree of infiltration and lymph node metastasis(P<0.05).Conclu-sion:nm23-H1 low expression plays a significant role in metastasis of human large intestinalcarcinoma and can be a good sign of metastasis.p53 over-expression plays a very importantrole in infiltration and metastasis as well as cell proliferation.
出处
《九江医学》
1996年第3期133-136,共4页
Jiujiang Medical Journal
