摘要
采用软骨细胞体外单层培养的方法，观察真菌毒素互隔交链孢霉甲基醌对幼兔关节软骨细胞作用的超微结构改变。结果表明该毒素能引起细胞质内脂滴增多，脂滴周围出现较高电子密度的颗粒，以及似胆固醇样的结晶，而且随毒素浓度增高而变化区域增大。
By using the methed of chondrocytes in monolayer culture, we observed the effect of mycotoxin alternariof methyl ether (AME) on the ultrastructure changes of rabbit articular chondrocytes. The results showed that the cultural chondrocytes revealed increased lipid droplet, which often gathered together in clumps with higher electron density particles and cholesterin-like crystals around them and that the higher the concentration of AME in the media, the more changed regions in the cytoplasm of chondrocytes.
出处
《西安医科大学学报》
CSCD
1996年第3期386-388,共3页
Journal of Xi'an Medical University(Chinese)
基金
国家"八.五"攻关项目
关键词
大骨节病
AME
软骨细胞
超微结构
mycotoxin
alternariol meythl ether
culture
chondrocytes
