摘要
为了探讨电离辐射诱发细胞凋亡的分子机制和寻求新型辐射防护剂，观察了具有硒谷胱甘肽过氧化物酶（ＧＰｘ）样活性的含硒有机化合物，Ｅｂｓｅｌｅｎ对６ＧｙＸ－射线照射诱发ＣＨＯ细胞凋亡的抑制作用，结果发现，１０μｍｏｌ／Ｌｅｂｓｅｌｅｎ具有一定的抗细胞凋亡的作用，其机制可能是通过清除电离辐射产生的活性氧而抑制ｘ－射线诱发的细胞凋亡。
Low dose x-ray radiation-induced apoptosis in CHO cells was studied using dye exclusion test,morphological analysis and DNA fragmentation assay. Ebselen,a selenooganic compound with peroxidase-like activity showed supression effect on radiation-induced apoptosis, The mechanism of ebselen may be dueto its antioxidant ability of eliminating radiation-induced reactive oxygen species.
出处
《第一军医大学学报》
CSCD
1996年第3期195-197,共3页
Journal of First Military Medical University
