摘要
Ｅｂｓｅｌｅｎ氨基酸衍生物的合成及抗脂质过氧化作用肖颖歆，刘秀芳，徐汉生，孙士勇，徐波（武汉大学化学系，武汉，４３００７２）（北京医科大学天然药物及仿生药物国家重点实验室）关键词２－苯基－１，２－苯并异硒唑－３（２Ｈ）－酮，苯并异硒唑酮，氨基酸衍生物...
Amino acid was used as a carrier of the active molecule──ebselen,which mimicked the properties of GSH-Px and was known as an anti-inflammatory drug.Eiht ebselen derivatives with amino acdethyl esters attached to the p-position of 2-phenyl moiety were prepared.2-(4'- Carboxylphenyl)-1,2-benzisoselenazol-3(2H)-one(1) was used as the intermediate prepared in good yield by cyclization of 2-chloroselenobenzoyl chloride with 4-amino benzoic acid in the presence of Et3N. Then l was treated with p-toluenesulfonates of amino acid ethyl ester,and the target compounds were obtained by further purification,Effects of compounds 1,2,3,4 as well as ebselen on Fe￣(2+)/cysteine-induced rat liver microsomal peroxidation were studied.Their IC_(50) were 30,22. 7,17.7,22.2 and 24μmol￣(-1),respectively.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1996年第6期914-916,共3页
Chemical Journal of Chinese Universities
关键词
脂质过氧化
苯并异硒唑酮
有机硒化合物
Ebselen,Benzisoselenazolone,Amino acid derivatives,Synthesis,Lipid peroxidation
