摘要
目的：评价阿片受体拮抗剂纳络酮（ＮＬＸ）和兴奋性氨基酸受体拮抗剂３－（２－羧基哌嗪－４－基）丙基－１－磷酸（ＣＰＰ）在脊髓损伤后的治疗效果。方法：以７．５ｇ重物从１０ｃｍ高处落下致伤大鼠Ｔ１０脊髓，伤后６０ｍｉｎ开始治疗，从鞘内给予ＮＬＸ１０ｍｇ／ｋｇ、ＣＰＰ１００ｍｇ／ｋｇ、甲基强的松龙（ＭＰ）３０ｍｇ／ｋｇ。结果：ＮＬＸ、ＣＰＰ、ＭＰ均显著促进了脊髓损伤后的神经功能恢复，减少组织损害，ＮＬＸ、ＣＰＰ和ＭＰ之间无显著差别，但较三者合用的效果为差。结论：脊髓损伤后的继发性损伤是多水平、多因素的综合作用，ＮＬＸ、ＣＰＰ与ＭＰ联合应用治疗急性脊髓损伤较之单一用药更有效。
To evaluate the effects of naloxone(NLX), an opiate antagonist, and CPP, an excitatory amino acid receptor antagonist in treating spinal cord injury. Methods: An impact of a 7.5 g weight dropped from 10 cm high was used to traumatize the T10 spinal cord. Treatment was started at 60 min posttrauma by intrathecal injection. The naloxone-treated rats received 10 mg/kg bolus, the CPP-treated rats 100 mg/kg, the methylprednisolone(MP)-treated rats 30 mg/kg. Results :NLX, CPP and MP all significantly improved neurological recovery and reduced tissue damage. There were not difference among them(P>0. 05). Effect of combined NLX, CPP and MP was better than that of NLX, CPP or MP alone. Conclusion: The secondary spinal cord injury posttrauma may be multi-level, multiple and composite factors.Beneficial actions of NLX and CPP, in combination with MP make them candidates for use in future clinical treatment.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1996年第6期535-538,共4页
Academic Journal of Second Military Medical University
基金
国家自然科学基金
