摘要
目的观察诺氟沙星预防鼠疫的效果。方法参照《中华人民共和国国家药典》成人剂量,用施新猷的动物折算系数法换算成家兔每日用药剂量60 mg／kg,分2次以灌胃法给实验3组动物预防用药3 d,第4天分别用含菌1．5×107个／只剂量感染实验3组和对照组动物。实验3组动物继续用药6 d后停药,观察诺氟沙星预防鼠疫的效果。结果实验3组动物存活率100％,对照组动物存活率为0。结论诺氟沙星预防实验感染动物鼠疫效果显著。
Objective To observe the efficacy of norfloxacin in preventing animals from infecting Yersinia pestis （ Y. pestis ）. Methods According to the adult dosage of norfloxacin stipulated by The National Pharmacopoeia of People＇s Republic of China, daily dosage for a rabbit was converted using a animal co-efficient converting method. 60 mg/kg of norfloxacin a day was given into rabbits＇ stomach in 3 experimental groups, twice a day for 3 days. Each of rabbits was injected with Y. pestis in a amount of fifteen millions on the fourth day. The 3 experimental groups continued this medication for 6 days. Then the efficacy of norfloxacin on prevention of Y. pestis infection was observed. Results Rabbits survival rate turned out to be 100% in the experimental groups and zero in the control group. Conclusions Norfloxacin is an obviously effective drug for preventing animal from infecting Y. pestis.
出处
《中国地方病学杂志》
CSCD
北大核心
2006年第6期601-602,共2页
Chinese Jouranl of Endemiology
基金
青海省科技厅重点科技攻关项目(2003-N-131)
关键词
诺氟沙星
预防
鼠疫
Norfloxaein
Prevention
Plague
