摘要
实验性感染大肠杆菌—败血霉形体病鸡,单剂量(5 mg.kg-1)内服司帕沙星,研究其组织动力学和残留情况。采用HPLC面积-内标法测定各组织中司帕沙星浓度,利用药动学分析软件MCPKP分析药-时数据。疾病模型鸡肝脏、肺脏和心脏中的药—时数据符合一级吸收三项指数方程,主要动力学参数为:t1/2α0.3505,0.8381,0.6005 h;t1/2β11.7802,13.8479,2.4578 h;tmax 1.0653,1.1397,0.7546 h;Cmax 3.3591,2.2951,1.7226μg.mL-1;AUC24.4230,30.663,5.3780 mg.L-1.h-1,Tcp(ther)81.0240,108.52,18.410 h。肾脏和肌肉组织中药-时数据符合一级吸收二项指数方程,主要动力学参数为:t1/2K 2.2287,7.5072 h;tmax1.4655,1.8644 h;Cmax1.9926,1.1317μg.mL-1;AUC9.8536,14.5240 mg.L-1.h-1;Tcp(ther)19.923,58.156 h。各组织中药物浓度降至0.001 mg.kg-1时需休药7 d。
A single dose （5 mg· kg^-1） of sparfloxacin was oral administered to experimentally induced E.coliMG chickens. The drug concentrations in tissues were detected by HPLC and the pharmacokinetics parameters were analyzed with MCPKP. The results showed that the liver, lung and heart concentration-time curves after oral administration were best described by a tri-exponential equation with the first order absorption. The main pharmacokinetic parameters were as follows： t1/2α0.3505,0.8381,0.6005 h;t1/2β11.7802,13.8479,2.4578 h;tmax1.0653,1.1397,0.7546 h;Cmax3.3591,2.295 1,1.7226μg·mL-1;AUC 24.4230,30.663,5.3780 ng·L-1·h-1,Tcp（ther）81.0240,108.52,18.410 h respectively. The kidney and muscle concentration-time data fitted the bi-exponential equation with first order absorption. Their main pharmacokinetic parameters were： t1/2k 2.2287,7.5072 h;tmax 1.4655,1.8644 h;Cmax1.9926,1.1317μg·mL-1;AUC 9.8536,14.5240mg·L-1·h-1;Tcp（ther）19.923,58.156h respectively. The withdrawal time of sparfloxacin concentrations in tissues reduce to 0.001 μg ·mL^-1 were suggested as 7 days.
出处
《东北农业大学学报》
CAS
CSCD
2006年第5期646-649,共4页
Journal of Northeast Agricultural University
基金
辽宁省博士启动基金(1040175)
辽宁省教育厅科学研究计(划202053102)项目
关键词
司帕沙星
大肠杆菌-败血霉形体感染鸡
组织动力学
残留
sparfloxacin
Escherichia coli.-Mycoplasma gallisepticu disease
chickens
pharmacokinetics
residues
