摘要
猪5只,单剂量30 mg/kg口服给药,进行代谢动力学研究。依据本实验建立的HPLC方法进行血液中药物含量测定。口服给药符合一级吸收一室开放模型:T1/2Ka=2.87 h,T1/2K=5.05 h,Tp=6.53 h,Cmax=0.28μg/mL,AUC=3.78 mg.L-1.h,说明喹烯酮口服给药后,其吸收较慢,消除较快,生物利用度较低。
A normal pig was given 30 mg/kg quinocetone in an oral dose. The concentrations of quinocetone in pig plasma were determined by HPLC developed in our laboratory. Plasma drug concentration-time course of quinocetone after oral administration of quinocetone was found to be fitted to one compartment open model with first order absorption and its pharmacokinetic parameters were as follows ： T1/2Ka = 2.87 h, T1/2K = 5. 05 h, Tp = 6.53 h, Cmax = 0.28μg/mL,AUC = 3.78 mg·L ^- 1·h. The results showed that the absorption and excretion of quino- cetone were slow and its availability was low after oral administration.
出处
《中国兽药杂志》
2005年第9期1-3,共3页
Chinese Journal of Veterinary Drug
