摘要
目的：探讨自由基对胆色素结石形成的影响。方法：用电子顺磁共振谱（ＥＰＲ）分析胆石，用ＦＴ－ＩＲ测定胆红素钙含量。结果：胆固醇结石的ＥＰＲ信号很弱或检测不出。胆色素结石则可同时具有自由基和过渡金属离子的ＥＰＲ特征，其中心谱线（ｇ＝２．００４０，线宽＝９．５Ｇ）由自由基引起，且强度与胆石中胆红素钙的含量正相关（ｒ＝＋０．９９５，Ｐ＜０．００１），结论：胆色素结石中存在源于胆红素类化合物的自由基。自由基对胆色素结五中胆红素聚合物的形成可能有重要影响。
Objective:To investigate the role of free radical in the formation of pigment gallstones. Meth-ods:Gallstones were assayed by electron paramagnetic resonance(EPR)spectroscopy. The contents of calcium bilirubinate in gallstones were determined by FT-IR, Results:Very weak or no EPR signals were detected from cholesterol gallstones, and the features of free radical and transition metal ions were found in pigment gallstones. The central line(q=2.0040,line width=9. 5G) in EPR spectra of pigment gallstones is produced by free radical,and its intensities correlated linearly with the contents of calcium bilirubinate in pigment gallstones(r=+0.995,P<0.001).Conclusion :Free radical existed in pigment gallstones,and it arose from bilirubin compounds in gallstones. Free radical might play an important role in the formation of bilirtibin polymers in pigment gallstones.
出处
《北京医科大学学报》
CSCD
1996年第5期361-362,370,共3页
Journal of Peking University(Health Sciences)
基金
国家自然科学基金
关键词
胆结石
自由基
Cholelithiasis
Bilirubin/anal
Free radicals
