摘要
目的:研究骨肉瘤组织中survivin蛋白的表达情况,探讨survivin与骨肉瘤发生发展及其预后的关系。方法:应用免疫组织化学S-P法对46例原发性骨肉瘤组织中survivin蛋白的表达水平进行检测。结果:46例骨肉瘤组织中survivin蛋白表达阳性率为63.0%(29/46),对照组12例骨软骨瘤组织中未见表达;survivin表达与外科Enneking分期有关,而与患者年龄、性别、肿瘤部位、大小、病理分型无关;survivin蛋白表达阳性者术后5年生存率显著低于表达阴性者(P<0.05)。结论:Survivin蛋白在骨肉瘤中高表达,这种特异性表达对促进骨肉瘤细胞恶性增殖具有重要作用,survivin可成为评价骨肉瘤预后的分子指标。
Objective To study the expression of survivin protein in human osteosareoma and its relationship with the occurrence and prognosis of osteosareoma. Methods The expression of survivin was detected by S-P immunohistochemical technique in 46 eases of human osteosareoma. Results The positive rate of survivin was 63.0% in 46 eases of osteosareoma and no survivin was detected in 12 eases of osteochondroma. The expression of survivin was correlated with Enneking stage but not correlated with age, sex, size of the tumor, the tumor＇s primary location and histological differentiation. The 5-year survival rate of the patients with survivin positive expression was much lower than that of the patients with survivin negative expression （ P 〈 0. 05）. Conclusion The high expression of survivin in osteosarcoma may play an important role in the proliferation of osteosareoma and survivin can be used to predict the prognosis of osteosareoma.
出处
《实用医学杂志》
CAS
2006年第9期985-987,共3页
The Journal of Practical Medicine
