摘要
目的：探讨子宫内膜异位症是否影响子宫内膜容受性而造成不孕。方法：前瞻性研究我院2004年1月到2005年6月经手术病理确诊的子宫内膜异位症不孕患者胚胎种植窗期血清孕激素、雌激素浓度，组织学分期和子宫内膜整合素av、β3的表达，并与同期已育妇女的指标作比较。结果：15例子宫内膜异位症不孕患者中工期和Ⅱ期共8例（研究1组），Ⅲ期和Ⅳ期共7例（研究2组），与16例对照组比较，血清孕激素和雌激素浓度差异无统计学意义。病理组织学确诊的黄体功能不足差异无统计学意义。子宫内膜整合素β3的表达差异无统计学意义，子宫内膜整合素av的表达差异有统计学意义（P〈0．05），且仅Ⅲ期和Ⅳ期子宫内膜异位症子宫内膜整合素av的表达差异有统计学意义（P〈0．01）。结论：初步证实Ⅲ～Ⅳ期子宫内膜异位症不孕患者子宫内膜容受性标记物-子宫内膜整合素av的表达下降，与其导致不孕和流产相关，值得进一步进行大样本的研究。
Objective： To investigate whether endometriosis affected the endometrial receptivity in terms of av.β3 integrin. Methods： Prospectively chose fifteen infertile women with endometriosis as the only cause of infertility as experimental group and sixteen fertile women as control group. Mid-luteal serum concentration of progesterone and estrodiol,as well as endometrial biopsies for histological dating and alpheV bate3 integrin expression was analyzed in each patient.The parameter of each group was compared.Results：Them were eight women diagnosed as minimal or mild （ stage Ⅰ and Ⅱ ） endometriosis （ subgroup Ⅰ ） and seven women diagnoses as moderate or severe （stage Ⅲand Ⅳ ） endometriosis （subgroup Ⅱ） by laparoscopy in experimental group. No stately significant difference between the two groups was observed for parameter of hormones, endometrial luteal phase dysfunction and bate3 integrin expression. However, av integrin expression decreased in experimental group. And only in moderate or severe endometriosis subgroup did this difference have statistical signifcance （ P 〈 0.01 ）. Conclusions： These results showed that moderate or severe endometriosis lead to decrease of endometrial receptivity, that may associated with infertility and miscarriage in those women. Further studies were needed to clarify the relationship between av integrin expression decrease and infertility in moderate or severe endometriosis associated infertility women.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2006年第10期622-624,共3页
Journal of Practical Obstetrics and Gynecology
基金
广东省医学科学技术研究基金资助项目(项目编号:A2004022)
