摘要
目的研究阿片受体在IL-1β致热大鼠发热过程中的作用及机制。方法经大鼠侧脑室微量注射纳洛酮和(或)IL-1β,观察大鼠体温变化情况,并测定下丘脑中cAMP含量和HSP70表达。结果纳洛酮能够减弱IL-1β致热效应,同时下丘脑中cAMP含量和HSP70表达水平也相应减少(P<0.01)。结论阿片受体拮抗剂纳洛酮能够抑制大鼠IL-1β性发热,其机制可能与降低下丘脑中cAMP的合成有关;同时可见HSP70表达水平降低。
Aim To study the role and mechanism of opioid receptor on IL-1β-induced fever. Methods Rats were dealed with intracerebreventricular administration of naloxone and/or IL-1β. Changes in body temperature were measured. The content of cAMP and HSP70 expression in hypothalamus were detected. Resuits Naloxone can limit IL-1β-induced fever and decrease the content of cAMP and HSP70 expression inhypothalamus（P 〈 0.01 ）. Conclusion The present study showed that the opioid receptor antagonist naloxone could inhibit IL-1β-induced fever in rats, and this mechanism might be related with the decrease of cAMP synthesis in hypothalamus; meanwhile the expression of HSP70 was reduced.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2006年第10期1180-1183,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No30270198)
