摘要
目的观察热应激对大鼠TNF-α性发热效应及下丘脑中cAMP含量的影响。方法①确定热应激后下丘脑HSP70表达的高峰时间;②观察热应激后大鼠TNF-α性发热效应及下丘脑cAMP含量的变化。结果下丘脑中HSP70表达在热应激后12 h达高峰值,热应激后可见TNF-α性发热幅度降低,同时抑制下丘脑中cAMP的含量。结论热应激能够减弱大鼠TNF-α性发热效应,且此作用很可能是通过高表达的HSP70来抑制下丘脑中cAMP的升高而实现的。
Aim To explore the effects of heat stress on TNF-α-induced fever and the content of cAMP in rat hypothalamus. Methods ①We examined the peak time of HSP70 expression in hypothalamus after heat stress; ②We studied the change of TNF-α-induced fever and the content of cAMP in hypothalamus after heat stress. Result The maximum hypothalamus was attained at expression 12 h after of HSP70 in heat stress.Heat stress limited TNF-α-induced fever and decreased the content of cAMP in hypothalamus. Conclusion Heat stress can inhibit TNF-α-induced fever in rats, and this effect may be related with the inhibition of cAMP synthesis induced by high expression HSP70 in hypothalamus.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2005年第9期1054-1057,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No30270198)
