摘要
目的:对何首乌中主要化学成分大黄素、大黄素甲醚、大黄素-8-O-β-D-吡喃葡萄糖苷、大黄素甲醚-8-O-β-D-吡喃葡萄糖苷以及2,3,5,4′-四羟基反式二苯乙烯-2-O-β-D-吡喃葡萄糖苷的含量在炮制过程中不同时间的动态变化进行研究,并分析探讨它们的变化规律。方法:采用反相高效液相色谱法,对炮制前后何首乌中5种主要成分进行含量测定。结果:所测5种成分的含量均明显降低。结论:炮制使何首乌中主要化学成分的含量均明显降低,提示临床上应用制首乌是否必要值得探讨。
Objective： To study the dynamic changes of Emodin, Physcion, Emodin-8-O-β-D-glueopyranoside, Physeion-8-O-β- D-glueopyranoside and 2,3,5,4＇ -tetrahydtoxysilbene-2-O-β-D-glucopyranoside in Polygonum multiflorum during preparation and analyze their changing laws. Methods： Five major constituents before and after preparation were determined by RP-HPLC methods. Resuits： The five ingredients decreased significantly after preparation. Conclusion ： The major chemical constituents of Polygonum multiflorum decrease significantly, suggesting the neeessarity of prepared Polygonum multiflorum in clinical application worths studing.
出处
《中药材》
CAS
CSCD
北大核心
2006年第10期1017-1019,共3页
Journal of Chinese Medicinal Materials
关键词
何首乌
化学成分
游离蒽醌
结合蒽酯
二苯乙烯苷
反柑高效液相色谱
Polygonum multiflorum Thunb.
Chemical constituents
Free anthraquinones
Combined anthraquinones
Stilbene glucoside
RP-HPLC
