摘要
近年来的研究表明,成年哺乳动物中枢神经系统存在神经干细胞,并且在整个成年期有持续的神经发生。中风能使齿状回颗粒下层和脑室下层的神经发生增加,新产生的神经元能够迁移到损伤区并表达已死亡神经元的标记物。这些研究为脑损伤后的自身修复带来了希望。本文作者主要对成年神经发生和调节以及中风诱导的神经发生和调节进行综述,并进一步探讨中风或其他脑损伤后神经再生的研究方向。
Recent evidence has shown that neurogenesis occurs throughout adulthood, and neural stem cells reside in the adult central nervous system （CNS） in mammals. Experimental stroke in adult mammals increases neurogenesis from neural stem cells or progenitor cells localed in dae dentate subgranular zone and the subvemricular zone lining the lateral ventricle. New neurons can migrate to the areas of damage regions and express morphological markers characteristic of died neurons. These findings bring hope for self-repair after brain injury. The author of this paper reviewed the adult neurogenesis and its regulation in vivo, and described evidence for stroke-induced neurogenesis and neuronal replacement in the adult, and discussed the future research direction.s about neurogenesis after stroke and other brain injuries,
出处
《中国康复理论与实践》
CSCD
2006年第8期656-658,共3页
Chinese Journal of Rehabilitation Theory and Practice
基金
国家重点基础研究发展计划-973计划项目(No.2003CB517104)
国家自然科学基金项目(No.30472184)
北京市自然科学基金项目(No.7050001
7032013)
北京市科技计划项目(No.D0204003000031)
关键词
神经发生
脑缺血
神经干细胞
综述
neurogenesis
cerebral ischemia
neural stem cell
review
